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Medical Director CNS

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ProQR Therapeutics is a NASDAQ-listed biotechnology company headquartered in Leiden, the Netherlands with an office in and Cambridge, Massachusetts, USA.

At ProQR, we are on a mission to edit RNA, treat disease and change lives. A team of 180+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is committed to pioneering transformative RNA therapies to make a difference in the lives of the communities we serve.

Our proprietary Axiomer™ RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), a protein which is present in all human cells, to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases. By harnessing the power of RNA editing, we aim to create a world where genetics inform your health - but never limit it.

Our Development department is currently looking for a Medical Director CNS (Full-time) to join our team.

The Development Department advances drug candidates from early research into clinical testing, ensuring they are thoroughly evaluated for safety and efficacy. Translational Development generates the data needed to move programs into the clinic, while Clinical Development designs and executes trials to demonstrate safety and efficacy in patients. Together, they connect science, medicine, and regulatory strategy to drive successful therapeutic development.

The Medical Director CNS serves as a strategic and scientific leader within Clinical Development, driving the advancement of ProQR's pipeline and contributing to improved patient outcomes. As a subject matter expert in CNS diseases, the Medical Director provides deep scientific and clinical input into the design, execution, analysis, and reporting of Phase I-III clinical studies. The role also supports regulatory submissions and preparation for commercial launch, while partnering cross-functionally to ensure high-quality development strategies. In addition, the Medical Director offers clinical insight to research teams on an ad-hoc basis, helping translate scientific discoveries into impactful therapeutic programs.

Location: Leiden, NL (on-site)

We expect our Medical Director CNS to have:

• MD (or equivalent) required; board certification in neurology, psychiatry or related CNS specialty required.

• Minimum 5+ years of experience in the biotechnology or pharmaceutical industry, with a proven leadership role in clinical development or related functions, including responsibility for the design, execution, analysis, and reporting of early- and/or late-phase clinical trials.

• Deep understanding of CNS disease biology, clinical trial methodology, biostatistics, and global regulatory requirements relevant to CNS drug development.

• Demonstrated expertise in CNS disorders, including an advanced understanding of CNS biomarker strategy and development (e.g., imaging, fluid biomarkers, digital biomarkers).

• Proven ability to foster effective cross-functional collaboration within global project teams and clinical study teams, with a focus on operational excellence and timely execution.

• Strong scientific and clinical network within the CNS community, including key opinion leaders, investigators, academic centers, and patient advocacy partners.

• Ability to build and maintain relationships with external stakeholders, including key opinion leaders, investigators, clinical sites, patient organizations, and CROs.

• Excellent leadership, communication, strategic thinking, and analytical problem-solving skills, with the ability to influence and guide cross-functional decision-making.

• Exceptional verbal and written communication skills in English, including experience representing clinical programs to internal leadership, external experts, and regulatory bodies.

• Proficiency in scientific/medical literature interpretation, clinical data analysis, and the use of digital and statistical tools relevant to clinical research.

Skills and competencies that are required for making the difference:

• Highly organized, analytical and detail-oriented

• Able to work in an ambitious, fast-paced environment

• Team-player

• Strong project planning and management skills, with outstanding written and verbal communication skills

• Creative and Critical thinker, with decision-making and problem-solving skills

• Pro-active and pragmatic self-starter, with a result-oriented mindset

• Excellent knowledge of spoken and written English

ProQR as an employer

As an employer, we value a diverse workforce in which people are encouraged to develop themselves both personally and professionally. We believe that when people are happy, energized and supported by an environment in which they can thrive, they can achieve extraordinary things.

We are committed to ensuring that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and valued.

We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

• 8% holiday allowance

• 30 vacation days

• Unlimited (un)healthy snacks and drinks

• We are looking for people who are inspired by our mission to edit RNA, treat disease and change lives. Are you up for the challenge?

Submit your application via the Apply button below. Please contact Silvia Catellani via if you have any questions.